Adult: For cases associated with diseases affecting the vestibular system: 25-100 mg daily in divided doses, based on clinical response. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral Motion sickness
Adult: As prevention and treatment of nausea, vomiting or dizziness associated with motion sickness: 25-50 mg given the night before or approx 1 hour before travelling; may repeat dose 24 hourly if needed. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: 2-5 years 6.25 mg once daily; 6-12 years 12.5 mg once daily; >12 years Same as adult dose. All doses may be given the night before or approx 1 hour before travelling; may repeat dose 24 hourly if needed. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
What are the brands available for Meclozine in Philippines?
CYP2D6 is the dominant metabolising enzyme of meclozine. Based on the annotation of the US Food and Drug Administration (US FDA) drug label for meclizine, the genetic polymorphism of CYP2D6 gene which results in poor-, intermediate-, extensive-, and ultrarapid metaboliser phenotypes may contribute to the larger inter-individual variability in meclizine exposure. Therefore, it is recommended to monitor for adverse reactions and clinical effects accordingly in patients with CYP2D6 polymorphism.
Administration
Meclozine May be taken with or without food.
Special Precautions
Patient with asthma, narrow-angle glaucoma, prostatic hyperplasia, bladder neck obstruction, urinary stricture, pyloric or duodenal obstruction. Patients with CYP2D6 polymorphism. Renal and hepatic impairment. Children and elderly. Pregnancy and lactation.
Adverse Reactions
Significant: Anticholinergic effects (e.g. blurred vision, urinary retention, xerostomia), CNS effects (e.g. drowsiness, memory impairment, dementia). Gastrointestinal disorders: Vomiting. General disorders and administration site conditions: Fatigue. Immune system disorders: Anaphylaxis. Nervous system disorders: Headache.
This drug may cause drowsiness, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor mental alertness.
Drug Interactions
Enhanced CNS depression with other CNS depressants (e.g. barbiturates). Prolonged and enhanced anticholinergic effects with MAOIs.
Food Interaction
May enhance the CNS depressant effect of alcohol.
Action
Description: Mechanism of Action: Meclozine, a piperazine derivative, inhibits vestibular end-organ receptors and prevents activation of central cholinergic pathways. Synonym(s): Meclizine. Onset: Approx 1 hour. Duration: Approx 24 hours. Pharmacokinetics: Absorption: Readily absorbed from the gastrointestinal tract. Time to peak plasma concentration: 3.1 ± 1.4 hours. Distribution: Volume of distribution: 7 L/kg. Metabolism: Metabolised in the liver into norchlorcyclizine. Excretion: Via urine and faeces as unchanged drug and metabolites. Elimination half-life: Approx 5-6 hours.
Chemical Structure
Meclozine Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4034, Meclizine. https://pubchem.ncbi.nlm.nih.gov/compound/Meclizine. Accessed Apr. 25, 2024.
R06AE05 - meclozine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
References
Annotation of FDA Label for Meclizine and CYP2D6. Pharmacogenomics Knowledgebase (PharmGKB). https://www.pharmgkb.org. Accessed 20/03/2024.Anon. Meclizine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 20/03/2024.Antivert Tablet; Tablet, Chewable (Casper Pharma LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 20/03/2024.Bonamine (Taisho Pharmaceuticals [Philippines], Inc). MIMS Philippines. http://www.mims.com/philippines. Accessed 21/03/2024.Buckingham R (ed). Meclozine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/03/2024.CYP2D6 - Meclizine. UpToDate Lexidrug, Pharmacogenomics Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 23/04/2024.Meclizine 25 Tablet (The Generic Pharmaceutical Company). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 23/04/2024.Meclizine. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 21/03/2024.Meclozine [Meclizine]. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 23/04/2024.Sea-Legs Tablets (G R Lane Health Products Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 20/03/2024.
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