Loxx 30/Loxx 60 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Duloxetine HCl

Indications/Uses

Major depressive disorder, generalized anxiety disorder, fibromyalgia & relief of diabetic peripheral neuropathic pain in adults.

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Dosage/Direction for Use

Major depressive disorder 30-60 mg daily. Can be increased by 30 mg/day. Max: 120 mg/day. Generalized anxiety disorder, fibromyalgia, diabetic peripheral neuropathy pain 30 mg cap once daily for 1 wk then 60 mg once daily. Can be increased by 30 mg/day. Max: 120 mg/day.

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Overdosage

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Administration

May be taken with or without food: Swallow whole, do not chew/crush/open cap.

Contraindications

Hypersensitivity. Concomitant use w/ MAOIs, serotonin precursors eg, tryptophan & thioridazine. Hepatic insufficiency, end-stage renal disease, severe renal impairment, uncontrolled narrow-angle glaucoma. Lactation.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Loxx 30/Loxx 60 detailed prescribing information

Special Precautions

History of mania, seizures, narrow angle glaucoma & liver dysfunction. Patients prone to suicide. Gradual reduction in dose is recommended. At least 14 days should elapse between discontinuation of MAOI & 5 days before initiating MAOI. Closely monitor patients for clinical worsening, suicidality & unusual changes in behaviour. Discontinue if jaundice or other evidence of clinically significant liver dysfunction, symptomatic orthostatic hypotension &/or syncope, symptomatic hyponatremia or urinary hesitancy & retention develop. Measure BP prior to therapy & monitor throughout treatment period. Discontinue any serotonergic or antidopaminergic agents. Use w/ aspirin, NSAIDs, warfarin & other anti-coagulants. Patients w/ substantial alcohol use. Smoking. Pregnancy. Childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Nausea, vomiting, dizziness, somnolence, headache, dry mouth, constipation, diarrhea, decreased appetite, hyperhidrosis, fatigue. Palpitations; vertigo; vision blurred; flatulence, dyspepsia, loose stools; chills/rigors, anorexia, appetite & decreased wt; increased wt; musculoskeletal pain/spasms, muscle cramp, myalgia; dysgeusia, lethargy, tremor, migraine & parasthesia/hypoesthesia; abnormal dreams, decreased libido & sleep disorder; anorgasmia/orgasm abnormal, erectile dysfunction, ejaculation delayed or ejaculation disorder, penis disorder; cough, pharyngolaryngeal pain & yawning; hot flush. Completed suicide.

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Drug Interactions

TCAs, phenothiazine, type 1C antiarrhythmics & other CNS agents.

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Storage

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Description

View Loxx 30/Loxx 60 description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antidepressants / Drugs for Neuropathic Pain

ATC Classification

N06AX21 - duloxetine ; Belongs to the class of other antidepressants.

Regulatory Classification

Presentation/Packing

Form

Loxx 30 DR cap 30 mg

Packing/Price

100's (P21.35/DR cap);30's (P21.35/DR cap)

Form

Loxx 60 DR cap 60 mg

Packing/Price

100's (P35.9/DR cap);30's (P35.9/DR cap)

Loxx 30/Loxx 60

duloxetine

Manufacturer:

Inventia Healthcare

Distributor:

Multicare