Lotram Special Precautions

Tramadol HCl should be used with caution and in reduced dosages in patients receiving CNS depressants like anaesthetic agents, phenothiazines, tranquilisers, sedative hypnotics, opioids etc. In patients with epilepsy, patients at the risk of seizures and along with the drugs like MAO inhibitors, neuroleptics etc, that lower seizure threshold. Tramadol HCl should be used during pregnancy and during labour only if the potential benefit justifies the potential risk to the fetus, because there are no adequate and well controlled studies for establishing safe use in pregnancy.
Respiratory depression is not reported with Tramadol HCl. However, it should be used with caution when administered with anaesthetic agents or alcohol to avoid risk of respiratory depression. It should be used with caution in patients with increased intracranial pressure, head injury, acute abdominal conditions and in patients who are dependent on opioids. In rare cases, convulsions have been observed in patients receiving Tramadol. Hence, Tramadol should be used with caution in patients with epilepsy with risk of seizures and in patients taking MAO inhibitors, neuroleptics.