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Losartan Potassium: Fluconazole: Losartan plasma levels may be elevated, increasing the anti-hypertensive and adverse effects.
Lithium: Plasma levels of lithium may be elevated, increasing the pharmacologic and adverse effects.
Rifamycins (eg, rifampin): Losartan plasma levels may be reduced, decreasing the anti-hypertensive effects.
Potassium-sparing diuretics (e.g. spironolactone), potassium supplements, salt substitutes containing potassium: May lead to increased serum potassium.
Hydrochlorothiazide: Alcohol, barbiturates, narcotics: Increased risk of orthostatic hypotension.
Antidiabetic agents: Dose adjustments of antidiabetic agent may be needed.
Anti-hypertensives: Actions of other antihypertensive agents may be potentiated.
Cholestyramine, colestipol resins: Absorption of hydrochlorothiazide may be impaired.
ACTH, corticosteroids: Increased risk of electrolyte depletion (eg, hypokalemia).
Pressor amines (eg, norepinephrine): Decreased response to pressor amine.
Nondepolarizing skeletal muscle relaxants (eg, tubocurarine): Responsiveness to muscle relaxant may be increased.
Lithium: Plasma levels of lithium may be elevated, increasing the risk of toxicity.
NSAIDs: Antihypertensive, diuretic, and natriuretic effects of hydrochlorothiazide may be reduced.
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