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The usual starting dose of losartan 50 mg once daily, with 25 mg recommended for patients with intravascular volume depletion (e.g. patient treated with diuretics). Losartan can be administered once or twice daily at total daily dose of 25 to 100 mg.
Hydrochlorothiazide is effective in dose of 12.5 mg to 50 mg once daily and can be given at doses of 12.5 to 25 mg as combination therapy with Losartan Potassium. To minimize the dose independent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy; or as prescribed by the physician.
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