Loratadine is given by mouth in a dose of 10 mg once daily. Children ages 2 to 5 years may be given 5 mg once daily and those ages 6 to 12 years may be given 10 mg once daily for seasonal allergic rhinitis and chronic urticaria. Patients with hepatic failure or mild renal insufficiency should be given loratadine 10 mg on alternate days initially.