Locoa Contraindications

Patients with peptic ulcer (see Precautions) [Gastric mucosal barrier decreased by inhibition of prostaglandin synthesis may aggravate peptic ulcer.]
Patients with severe blood abnormality [Blood disorder may develop, aggravating blood abnormality.]
Patients with severe liver disorder [Abnormal hepatic function may develop, aggravating liver disorder.]
Patients with severe renal disorder [Renal blood flow decreased by inhibition of prostaglandin synthesis, among others, may aggravate renal disorder.]
Patients with severe cardiac dysfunction [Water and sodium retention induced by inhibition of prostaglandin synthesis may aggravate cardiac dysfunction.]
Patients with severe hypertension [Water and sodium retention induced by inhibition of prostaglandin synthesis may further increase blood pressure.]
Patients with a history of hypersensitivity to the components of Esflurbiprofen (LOCOA) or flurbiprofen.
Patients with current or previous aspirin-induced asthma (asthmatic attacks induced by nonsteroidal anti-inflammatory analgesics and other relevant drugs) [Asthmatic attacks may be induced.]
Patients on enoxacin hydrate, lomefloxacin, norfloxacin, or prulifloxacin (see Interactions).
Women in late pregnancy (see Use in Pregnancy & Lactation).