Lizod

Nosocomial pneumonia; community-acquired pneumonia; complicated skin & soft tissue infections caused by susceptible organisms.

Adult 600 mg bid for 10-14 days. Max treatment duration: 28 days. Administer IV infusion over 30-120 min.

Should be taken with food.

Hypersensitivity. Not to be used in patients taking products inhibiting monoamine oxidases A or B (eg, phenelzine, isocarboxazid, selegiline, moclobemide) or taking any such products w/in 2 wk. Patients w/ uncontrolled HTN, phaeochromocytoma, carcinoid, thyrotoxicosis, bipolar depression, schizoaffective disorder, acute confusional states. Concomitant use w/ SSRIs, TCAs, serotonin 5-HT1 receptor agonists (triptans), directly & indirectly acting sympathomimetic agents (including the adrenergic bronchodilators, pseudoephedrine & phenylpropanolamine), vasopressive agents (eg, epinephrine, norepinephrine), dopaminergic agents (eg, dopamine, dobutamine), pethidine or buspirone. Lactation.

Myelosuppression. Close monitoring of blood counts in patients w/ pre-existing anaemia, granulocytopenia or thrombocytopenia; are receiving concomitant medications that may decrease Hb levels, depress blood counts or adversely affect platelet count or function; have severe renal insufficiency; receive more than 10-14 days of therapy. Close monitoring of Hb levels, blood counts & platelet counts wkly is recommended during therapy. Antibiotic-associated diarrhoea & colitis including pseudomembranous colitis & C. difficile-associated diarrhoea; discontinue & adequate therapeutic measures should be initiated immediately if it occurs. Lactic acidosis; mitochondrial dysfunction. Peripheral or optic neuropathy. Drugs inhibiting peristalsis. Serotonin syndrome may occur if co-administered w/ serotonergic agents, including antidepressants eg, SSRIs. Currently taking or who have recently taken anti-TB medications. History of seizures or risk factors for seizures. Concomitant use w/ MAOIs is not recommended. Use w/ tyramine-rich foods. Superinfection. Patients w/ DM or other conditions associated w/ glucose intolerance; patient on controlled Na diet. May impair the ability to drive & use machine. Severe renal & hepatic impairment. Fertility impairment. Pregnancy. Childn & adolescents <18 yr.

Candidiasis, oral candidiasis, vag candidiasis, fungal infection; anemia; insomnia; headache, taste perversion (metallic taste), dizziness; HTN; diarrhoea, nausea, vomiting, localised or general abdominal pain, constipation, dyspepsia; abnormal LFT, increased AST, ALT or alkaline phosphatase; pruritus, rash; increased BUN; fever, localised pain; increased LDH, creatinine kinase, lipase amylase or non-fasting glucose, decreased total protein, albumin, Na or Ca, increased or decreased K or bicarbonate, increased neutrophils or eosinophils, decreased Hb, haematocrit, or RBC count, increased or decreased platelet or WBC count.

Concomitant use w/ MAOIs & tyramine-rich foods. Increased BP w/ pseudoephedrine & phenylpropanolamine HCl. May cause serotonin syndrome w/ dextromethorphan & serotonergic agents including antidepressants eg, SSRIs. Decreased C_max & AUC w/ rifampicin. Decreased mean max INR w/ warfarin.

Other Antibiotics

J01XX08 - linezolid ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.

Rx