Liosal Dosage/Direction for Use

Baclofen (Liosal) is given orally in divided doses, preferably with or after food or milk. The initial dose of baclofen is 5 mg three times daily for 3 days, increased to 10 mg three times daily for 3 days, then in similar increments and intervals until either a dose of 20 mg three times daily is reached or until the desired therapeutic effect is obtained. Higher doses have been used. Doses of more than 80 to 100 mg daily are not generally recommended although doses of up to 150 mg daily have been given to carefully to supervised patients.
In the UK a dosage range of 0.75 to 2 mg/kg daily has been used for children; in children over 10 years a maximum daily dosage of 2.5 mg/kg may be given. It is usual to start with a low dose of 2.5 mg given four times daily, increased cautiously about 3 days until the desired therapeutic effect is obtained. The recommended daily maintenance doses are: 12 months to 2 years, 10 to 20 mg; 2 to 6 years, 20 to 30 mg; 6 to 10 years, 30 to 60 mg.