Limoclav Indications/Uses

Amoxicillin-clavulanate should be used in accordance with local official antibiotic prescribing guidelines and local susceptibility data.
Adult Formulations: Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites when caused by amoxicillin-clavulanate-susceptible organisms: Upper respiratory tract infections (including ENT) e.g. recurrent tonsillitis, sinusitis, otitis media, typically caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes. Lower respiratory tract infections e.g. acute exacerbations of chronic bronchitis, lobar, and bronchopneumonia, are typically caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Genitourinary tract infections e.g. cystitis, urethritis, pyelonephritis, and female genital infections typically caused by Enterobacteriaceae (mainly Escherichia coli), Staphylococcus saprophyticus and Enterococcus species and gonorrhea caused by Neisseria gonnorhoeae. Skin and soft tissue infections are typically caused by Staphylococcus aureus, Streptococcus pyogenes, and Bacteroides species. Bone and joint infections e.g. osteomyelitis typically caused by Staphylococcus aureus, where more prolonged therapy may be appropriate. Other infections e.g. septic abortion, puerperal sepsis, intra-abdominal sepsis.
Pediatric Formulations: Co-amoxiclav is indicated for short-term treatment of bacterial infections at the following sites when caused by amoxicillin-clavulanate sensitive organisms: Upper respiratory tract infections (including ENT) e.g. recurrent tonsillitis, sinusitis, otitis media typically caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes. Lower respiratory tract infections e.g. acute exacerbations of chronic bronchitis, lobar, and bronchopneumonia typically caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Genitourinary tract infections e.g. cystitis, urethritis, pyelonephritis, female genital infections typically caused by Enterobacteriacea (mainly Escherichia coli), Staphylococcus saprophyticus and Enterococcus species and gonorrhea caused by Neisseria gonorrhoeae. Skin and soft tissue infections are typically caused by Staphylococcus aureus, Streptococcus pyogenes, and Bacteroides species.
Amoxicillin-Clavulanate Pediatric Three Times Daily: The pediatric three times daily dosing regimen is also indicated for the following infections: Bone and joint infections e.g. osteomyelitis typically caused by Staphylococcus aureus, where more prolonged therapy may be appropriate. Other infections e.g. septic abortion, puerperal sepsis, intra-abdominal sepsis.
All Formulations: A comprehensive list of sensitive organisms is provided in Pharmacology: Pharmacodynamics: Mechanism of Action under Actions. Some members of these species of bacteria produce beta-lactamase, rendering them insensitive to amoxicillin alone (see Pharmacology: Pharmacodynamics under Actions).
Susceptibility to amoxicillin-clavulanate will vary with geography and time. Local susceptibility data should be consulted where available, and microbiological sampling and susceptibility testing performed where necessary. Infections caused by amoxicillin-susceptible organisms are amenable to Co-amoxiclav treatment due to their amoxicillin content. Mixed infections caused by amoxicillin-susceptible organisms in conjunction with amoxicillin-clavulanate-susceptible beta-lactamase-producing organisms may therefore be treated with Co-amoxiclav.