Limoclav Adverse Reactions

Gastrointestinal: Diarrhea, pseudomembrane colitis, emesis, indigestion, nausea, and stomatitis have been reported. Candidiasis and antibiotic-associated colitis (including pseudomembranous colitis and hemorrhagic colitis) have been reported rarely. The overall incidence of side effects, and in particular nausea, increased with the higher recommended dose. If gastrointestinal reactions are evident, they may be reduced by taking Co-Amoxiclav at the start of the meal. As with other antibiotics, the incidence of gastrointestinal side effects may be raised in children under two years. In clinical trials, however, only 4% of children under two years were withdrawn from treatment.
Liver: Moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted in patients with ampicillin class antibiotics but the significance of these findings is unknown. Hepatic dysfunction, including increases in serum transaminases (AST and/or ALT), serum bilirubin, and/or alkaline phosphate, has been infrequently reported with amoxicillin; potassium clavulanate. It has been reported more commonly in the elderly, in males, or in patients on prolonged treatment. The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic hepatocellular changes. The onset of signs/symptoms of hepatic dysfunction may occur during or several weeks after therapy has been discontinued. The hepatic dysfunction which may be severe is usually reversible. On rare occasions, death has been reported.
Hypersensitivity Reactions: Skin rashes (urticarial and erythematous rashes) sometimes occur. Rarely erythema multiform, Steven-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, acute generalized exanthematous pustulosis, and angioedema have been reported rarely. Treatment should be discontinued if one of these disorders occurs. In common with other β-lactamase antibiotics, angioedema, anaphylaxis serum sickness-like syndrome and hypersensitivity vasculitis have been reported.
Blood: As antibiotic other β-lactam, reversible leucopenia (including hypersensitivity and granulocytopenia), reversible thrombocytopenia and hemolytic anemia, thrombocytopenic purpura, eosinophilia, leucosis, agranulocytosis have been reported.
Central Nervous System: Side effects, such as reversible hypersensitivity, dizziness, headache, and convulsions have been reported rarely. Convulsions may occur in patients with impaired renal functions or those receiving a high dose.
Renal: Interstitial nephritis and hematuria have been reported rarely.
Other: Sometimes, dental discoloration has been reported rarely in children.