Levetrax Dosage/Direction for Use

Adults and Children over 12 years: The usual dosage is 1-2 g of Ceftriaxone once daily (every 24 hours). In severe cases or in infections caused by moderately sensitive organisms, the dosage may be raised to 4 g, once daily.
Duration of Therapy: The duration of therapy varies according to the course of the disease. As with antibiotic therapy in general, administration of Ceftriaxone should be continued for a minimum of 48-72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained.
Combination Therapy: Synergy between Ceftriaxone and aminoglycosides has been demonstrated with many gram-negative bacteria under experimental conditions. Although enhanced activity of such combinations is not always predictable, it should be considered in severe, life threatening infections due to microorganisms such as Pseudomonas aeruginosa. Due to chemical incompatibility between Ceftriaxone (Rocephin) and aminoglycosides, the two drugs must be administered separately at the recommended dosages.
Chemical incompatibility with Ceftriaxone has also been observed with IV administration of amsacrine, vancomycin and fluconazole.
Special Dosage Instructions: Patients with Hepatic impairment: In patients with liver damage, there is no need for the dosage to be reduced provided renal function is not impaired.
Patients with Renal Impairment: In patients with impaired renal function, there is no need to reduce the dosage of Ceftriaxone provided hepatic function is not impaired. Only in cases of preterminal renal failure (creatinine clearance <10 ml/min) should the Ceftriaxone dosage not exceed 2 g daily. Ceftriaxone is not removed by peritoneal- or hemodialysis. In patients undergoing dialysis no additional supplementary dosing is required following the dialysis.
Patients with Severe Renal and Hepatic Impairment: In patients with both severe renal and hepatic dysfunction, clinical monitoring for safety and efficacy is advised.
Elderly: The dosages recommended for adults require no modification in elderly patients, provided there is no severe renal and hepatic impairment.
Children: Neonates, infants and children up to 12 years: The following dosage schedules are recommended for once daily administration: Neonates (up to 14 days): 20-50 mg/kg body weight once daily. The daily dose should not exceed 50 mg/kg. Ceftriaxone is contraindicated in premature neonates up to a postmenstrual age of 41 weeks gestational age + chronological age.