Lacibloc Special Precautions

4 mg: As with other calcium antagonists, lacidipine should be used with caution in patients with poor cardiac reserve.
As with other dihydropyridine calcium antagonists lacidipine should be used with care in patients with unstable angina pectoris.
Lacidipine should be used with caution in patients with impaired liver function because antihypertensive effect may be increased. There is no evidence that lacidipine impairs glucose tolerance or alters diabetic control.
6 mg: Lacidipine should be used with caution in patients with hypotension, in patients whose cardiac reserved are poor, and in those with heart failure since deterioration of heart failure has been noted. Lacidipine should not be used in cardiogenic shock, in patients who have recently suffered a myocardial infarction, or in acute unstable angina. Lacidipine should not be used to treat an angina attack in chronic stable angina. In patients with severe aortic stenosis, Lacidipine may increase the risk of developing heart failure. Sudden withdrawal of Lacidipine might be associated with an exacerbation of angina. The dose may be needed to be reduced in patients with hepatic impairment.
In specialized studies, Lacidipine has been shown not to affect the spontaneous function of the SA node or to cause prolonged conduction within the AV nodes. However, the theoretical potential for a calcium antagonist to affect the activity of the SA and AV nodes should be noted, and therefore Lacidipine (Lacibloc) should be used with caution in patients with pre-existing abnormalities in the activity of the SA and AV nodes. As has been reported with other dihydropyridine calcium channel antagonists, Lacidipine (Lacibloc) should be used with caution in patients with congenital or documented acquired QT prolongation.
Lacidipine (Lacibloc) should also be used with caution in patients treated concomitantly with medications known to prolong the QT interval such as, class I and III antiarrhythmics, tricyclic antidepressants, some antipsychotics, antibiotics (e.g. erythromycin) and some antihistamines (e.g. terfenadine).