Lacibloc Mechanism of Action

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Full Prescribing Info

Action

Pharmacology: Pharmacokinetics: Lacidipine is rapidly but poorly absorbed from the gastrointestinal tract following oral administration and undergoes extensive first-pass metabolism; the bioavailability has been reported to be 2 to 9%, or 18.5% (range 4 to 52%) using a more sensitive assay method. It is more than 95% bound to plasma proteins. Lacidipine is eliminated by metabolism in the liver and metabolites are excreted mainly by the biliary route. About 70% of an oral dose is eliminated in the faeces, the remainder in the urine. The average steady-state terminal elimination half-life of lacidipine is 13 to 19 hours.

lacidipine

Manufacturer:

Ultramed

Distributor:

Ultramed