Patients with respiratory tract/skin and soft tissue infections: Adults: The usual dose is 250 mg twice daily although this may be increased to 500 mg twice daily in severe infections. The usual duration of treatment is 6 to 14 days.
Children older than 12 years: As for adults.
Children younger than 12 years: Use of clarithromycin tablets are not recommended for children younger than 12 years. Clinical trials have been conducted using clarithromycin paediatric suspension in children 6 months to 12 years of age. Therefore, children under 12 years of age should use clarithromycin paediatric suspension (granules for oral suspension).
Clarithromycin may be given without regard to meals as food does not affect the extent of bioavailability.
Eradication of H. pylori in patients with duodenal ulcers (Adults): The usual duration of treatment is 6 to 14 days.
Triple Therapy: Clarithromycin 500 mg twice daily and lansoprazole 30 mg twice daily should be given with amoxicillin 1000 mg twice daily.
Triple Therapy: Clarithromycin 500 mg twice daily and lansoprazole 30 mg twice daily should be given with metronidazole 400 mg twice daily.
Triple Therapy: Clarithromycin 500 mg twice daily and omeprazole 40 mg daily should be given with amoxicillin 1000 mg twice daily or metronidazole 400 mg twice daily.
Triple Therapy: Clarithromycin 500 mg twice daily and omeprazole 20 mg daily should be given with amoxicillin 1000 mg twice daily.
Elderly: As for adults.
Renal Impairment: In patients with renal impairment with creatinine clearance less than 30 mL/min, the dosage of clarithromycin should be reduced by one-half, i.e. 250 mg once daily or 250 mg twice daily in more severe infections. Treatment should not be continued beyond 14 days in these patients.
Mode of Administration: Oral.
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