Konakion MM Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Phytomenadione

Indications/Uses

Hemorrhage or risk of hemorrhage as a result of severe hypoprothrombinemia (ie, deficiency of clotting factors II, VII, IX & X) including overdosage of coumarin-type anticoagulants, their combination w/ phenylbutazone & other forms of hypovitaminosis K (eg, obstructive jaundice, liver & intestinal disorders, prolonged administration of antibiotics, sulfonamides or salicylates). Prophylaxis & treatment of hemorrhagic disease in newborn.

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Dosage/Direction for Use

Adult Severe or life-threatening hemorrhage (eg, during anticoagulant therapy) 5-10 mg slow IV given at least 30 sec together w/ fresh frozen plasma (FFP) or prothrombin complex conc (PCC). May be repeated as needed. Patient w/ asymptomatic high INR w/ or w/o mild hemorrhage INR 5-9: 0.5-1 mg + warfarin, INR >9: 1 mg + warfarin; INR 5-8 & >8: 1-2 mg + acenocoumarol; INR 5-9 & >9: 2-5 mg + phenprocoumon, INR >10 Individually adapted doses. Elderly 0.5-22 mg IV. Major bleeding 5-10 mg + warfarin + FFP or PCC; 5 mg + acenocoumarol + FFP or PCC; 5 mg or 10 mg + phenprocoumon + PCC. Life-threatening bleeding 10 mg + warfarin + FFP, PCC or recombinant factor VIIa.

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Overdosage

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Contraindications

Hypersensitivity. Should not be administered IM. Careful monitoring in patients w/ severely impaired liver function. Not recommended to be given to expectant mothers. Not recommended for nursing mothers.

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Special Precautions

Carefully monitor INR in patients w/ severe hepatic impairment. Not recommended for expecting/nursing mothers as prophylaxis & treatment of hemorrhagic disease in the newborn.

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Use In Pregnancy & Lactation

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Drug Interactions

Antagonize effect of coumarin-type anticoagulants. Impaired action w/ anticonvulsants.

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Storage

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Description

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Action

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MIMS Class

Haemostatics

ATC Classification

B02BA01 - phytomenadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.

Regulatory Classification

Presentation/Packing

Form

Konakion MM soln for inj 10 mg/mL

Packing/Price

1 mL x 5 × 1's

Konakion MM

phytomenadione

Manufacturer:

Cenexi SAS

Distributor:

Zuellig