Should not be administered to patients with hematopoietic disorders such as neutropenia or thrombocytopenia, haemorrhagic diathetis or other haemorrhagic disorders associated with a prolonged bleeding time, or conditions with an increased risk of bleeding such as gastrointestinal ulcers, acute cerebral hemorrhage or, several liver dysfunctions. Full blood counts should be performed within two weeks during the first 3 months of therapy. If discontinued during the period, a full blood count should be performed within 2 weeks of stopping of treatment. Consideration should be given in stopping the therapy 10-14 days before elective surgery.