Adapalene Gel microsphere should be applied to the acne affected areas once a day before retiring and after washing. A thin film of gel should be applied, with the fingertips, avoiding the eyes and lips (see Precautions as follows). Ensure that the affected areas are dry before application.
During the early weeks of therapy, an apparent exacerbation of acne may occur. This is due to the action of the medication on previously unseen lesions and should not be considered a reason to discontinue therapy.
Therapeutic results may be noticed within eight to twelve weeks of treatment.
Since it is customary to alternate therapies in the treatment of acne, it is recommended that the physician assess the continued improvement of the patient after three months of treatment with Adapalene Gel Microsphere.
With patients for whom it is necessary to reduce the frequency of application or to temporarily discontinue treatment, frequency of application may be restored or therapy resumed once it is judged that the patient can again tolerate the treatment.
If patients use cosmetics, these should be non-comedogenic and non-astringent.
Paediatric population: The safety and effectiveness of Adapalene Gel microsphere have not been studied in children below 12 years of age. Adapalene gel microsphere should not be used in patients with severe acne.
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