Klenzit-MS Description

Opaque white smooth homogeneous gel.
Each g of gel contains: Adapalene (as microspheres) 1 mg in an aqueous gel base.
Adapalene Gel microsphere, containing Adapalene in a Microsponge delivery system, is used for the topical treatment of acne vulgaris. Each gram of Adapalene Gel microsphere contains adapalene 0.1% (1 mg), a retinoid analogue for the topical treatment of acne vulgaris, as microspheres and preservatives, viz. methyl hydroxybenzoate and phenoxyethanol.
Microsponge is a polymeric delivery system consisting of porous microspheres, which are round microscopic particles made of synthetic polymer. These particles entrap the active drug, Adapalene, in the microsponge system. After the product is applied, the entrapped drug is then delivered to the skin in a controlled time-release pattern or a pre-programmed manner after it has been applied to the skin.
The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naptholic acid. Adapalene is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula of adapalene is C₂₈H₂₈O₃, and its molecular weight is 412.52.