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Clindamycin, when administered orally and parenterally, has been associated with ulcerative colitis, which may result in patient death. Use of the topical formulation of clindamycin results in the absorption of the antibiotic from the skin surface. Topical and systemic clindamycin have been reported to cause diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis).
Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of oral and parenteral therapy with clindamycin.
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