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As Adapalene has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentration of alcohol, astringents, spices or lime) should be used with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol or salicylic acid in combination with Adapalene Microspheres + Clindamycin Phosphate Gel.
If these preparations have been used, it is advisable not to start therapy with Adapalene Microspheres + Clindamycin Phosphate Gel, until the effects of such preparations in the skin have subsided.
Clindamycin has neuromuscular blocking properties. Therefore, it should be used with caution in patients receiving neuromuscular agents as that may enhance the action of these neuromuscular blocking agents.
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