Kidsolone

Each mL syrup contains: Prednisolone (as Sodium Phosphate) 1 mg.
Prednisolone is glucocorticoid given, as the free alcohol or in esterified form, orally or parentally, in the treatment of various disorders in which corticosteroids are indicated, except adrenal deficiency states. It is also given by local injection, applied rectally and applied topically as eye drops or ear drops. Adverse effects are those of corticosteroids in general. It has relatively slight mineralocorticoid effects.

Pharmacology: Pharmacokinetics: Prednisolone and Prednisone are both readily absorbed from the gastro-intestinal tract, but whereas prednisolone already exist in metabolically active form, prednisone must be converted in the liver to its active metabolite, prednisolone. In general, this conversion is rapid so that prednisone has a preconversion biological half-life of only about 60 minutes. Hence, although prednisone has been estimated to have only about 80% the bioavailability. This difference is of little consequence when seen in the light of intersubject variation in the pharmacokinetics of prednisolone itself; bioavailability also depends on the dissolution rates of the tablet formulations. Nevertheless, prednisolone is the more reliably absorbed of the two corticosteroids, particularly some liver diseases where the conversion of prednisone may be diminished.
Peak plasma concentrations of prednisolone are obtained 1 or 2 hours after administration by mouth, and it has usual plasma half-life of 2 to 4 hours. Its initial absorption, but not its overall bioavailability, is affected by food.
Prednisolone is excreted in the urine as free and conjugated metabolites, together with an appreciable proportion of unchanged prednisolone. Prednisolone crosses the placenta and small amounts are excreted in breast milk.
Prednisolone has a biological half-life lasting several hours, intermediate between those of hydrocortisone and the longer acting glucocorticoids, such as dexamethasone. It is this intermediate duration of action in which makes it suitable for the alternate-day administration regimens which has been found to reduce the risk of adrenocortical insufficiency, yet provide adequate corticosteroid coverage in some disorders.

Suppression of inflammatory and allergic disorders, inflammatory bowel disease, asthma, immunosuppression, rheumatic disease.

The dosage recommendation in children based on kilogram body weight is 1-2 mg/kg body weight given once or in divided doses. Short course therapy of 3 to 5 days needs tapering of dose.

The dose of corticosteroids required to diminish corticotrophin secretion with consequent atrophy of the adrenal cortex and the time required for its occurrence vary from patient to patient. Acute adrenal insufficiency may occur during prolonged treatment or on cessation of treatment and may be precipitated by stressful situation. Growth retardation in children has been reported. High doses of corticosteroids administered during pregnancy may cause fatal or neonatal adrenal suppression.

High doses of corticosteroids administered during pregnancy may cause fatal or neonatal adrenal suppression.

Large doses of corticosteroids or of corticotrophin may produce Cushingoid symptoms typical of hyperactivity of the adrenal cortex, with moon-face sometimes with hirsutism, buffalo hump, flushing, increased bruising, ecchymoses, striae and acne, sometimes leading to a fully developed Cushing's syndrome. If administration is discontinued these symptoms are usually reversed, but sudden cessation is dangerous. Other adverse effects include amenorrhea, hyperhidrosis, skin thinning, ocular changes including development of cataract, mental and neurological disturbances, intracranial hypertension, acute pancreatitis, and aseptic necrosis of bone. An increase in coagulability of the blood may lead to thromboembolic complications. Peptic ulceration has been reported. Muscle weakness and wasting occur occasionally, particularly when corticosteroids are taken in large doses. The former arises from the mineralocorticoid properties of corticosteroids, the latter from their glucocorticoid properties and is most evident with triamcinolone.

Store at temperatures not exceeding 30°C.

Corticosteroid Hormones

H02AB06 - prednisolone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.

Rx