Keptrix Dosage/Direction for Use

Intravenous Injection: Ceftriaxone (KEPTRIX) 1 g is dissolved in 10 mL of Sterile Water for Injection. Administered by intravenous injection lasting two to four minutes.
Intramuscular Injection: Ceftriaxone (KEPTRIX) 1 g is dissolved in 3.5 mL of 1% Lidocaine solution and administered by deep intramuscular injection. If more than 1 g is to be injected intramuscularly then the dose should be divided between more than one site.
Standard Dosage: Adults and children over 12 years: Administer 1 to 2 g once daily (every 24 hours) in severe cases the dosage may be raised to a maximum dose of 4 g administered once daily.
Infants and children: 20 to 50 mg/Kg once daily; for severe infections up to 80 mg/Kg once daily may be given.
Neonates: The maximum dose should not exceed 50 mg/Kg once daily; intravenous doses in neonates should be given over 60 minutes. Doses above 50 mg/Kg should be administered by intravenous infusion only.
Special Dosage: In bacterial meningitis in infants and children, treatment begins with doses of 100 mg/Kg body weight (not to exceed 4 g) once daily. The duration of therapy is as follows: Neisseria meningitis, 4 days; Streptococcus pneumoniae, 7 days; Haemophilus influenzae, 6 days; Susceptible Enterobacteriaceae, 10-14 days.
A reduction in dosage may be necessary in patients with severe renal impairment and in those with both impaired renal and hepatic function; plasma concentrations should be monitored in such patients.