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Carvedilol should be used in pregnant women or nursing mothers only if the potential benefits outweigh the potential risk. There is no adequate clinical experience with Carvedilol in pregnant women. Carvedilol is excreted in human milk.
Beta-blockers reduce placental perfusion, which may result in intrauterine fetal death, and immature and premature deliveries. In addition, adverse effects (especially hypoglycemia and bradycardia) may occur in fetus and neonate. There may be an increased risk of cardiac and pulmonary complications in the neonate in postnatal period. There is no evidence from animal studies that carvedilol has any teratogenic effects.
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