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Anti-Inflammatory Agent and Anti-Infective.
Pharmacology: Pharmacodynamics: Prednisolone acetate is a synthetic adrenocorticoid with the general properties of prednisolone. Adrenocorticoids diffuse across cell membranes to complex with cytoplasmic receptors and subsequently stimulate the synthesis of enzymes with anti-inflammatory effects. Glucocorticoids inhibit the oedema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation. Prednisolone acetate has, on a weight-to-weight basis, a potency three to five times that of hydrocortisone.
Pharmacokinetics: Prednisolone acetate has been shown to penetrate rapidly into the cornea after topical application of a suspension preparation. Aqueous humour Tmax occurs between 30 and 45 minutes after installation. The half-life of prednisolone acetate in human aqueous humour is approximately 30 minutes.
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