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Pregnancy: Studies in animals have not shown evidence of harm to the fetus. However, there is limited experience in pregnant women, and animal data may not reliably predict human response. Isosorbide dinitrate should only be used during pregnancy if clearly necessary and under medical supervision.
Lactation: Available evidence is insufficient to determine the risk to the breastfed infant. Nitrates are known to be excreted in breast milk and may cause methemoglobinemia in infants. The extent of excretion of isosorbide dinitrate and its metabolites in human breast milk has not been established. Therefore, caution should be exercised when administering isosorbide dinitrate to lactating women.
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