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Adults: Intravenous: A dose between 2 mg and 12 mg per hour is usually effective. Doses up to 20 mg per hour may be given and should be adjusted based on the patient's response.
Intra-coronary: The typical dose is 1 mg as a bolus injection before balloon inflation. Additional doses may be given if needed, but the total should not exceed 5 mg within 30 minutes.
Children: The safety and efficacy of Isosorbide Dinitrate Injection have not yet been established in children.
Elderly: No dose adjustment is necessary.
Renal and Hepatic Impairment: Isosorbide Dinitrate Injection should be used with caution in patients with severely impaired renal or hepatic function.
Method of administration: Isosorbide Dinitrate Injection is a concentrated solution and must be diluted before use. It should not be given as a direct bolus injection, except via the intra-coronary route before balloon inflation. A 50% dilution is recommended for intra-coronary use.
Isosorbide Dinitrate Injection can be administered by intravenous infusion using a compatible solution. Prepared admixtures should be given via infusion pump or syringe pump with a glass or rigid plastic syringe. Blood pressure and pulse should be closely monitored during administration and the dose adjusted according to clinical response.
For intravenous or intracoronary use only.
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