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There have been reports of overdosage at doses up to approximately twice the recommended therapeutic dose, which may be fatal. The most significant adverse reactions reported were severe neutropenia and severe diarrhoea.
There is no known antidote for Irinotecan Hydrochloride Trihydrate Injection. Maximum supportive care should be instituted to prevent dehydration due to diarrhoea and to treat any infectious complications.
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