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Chronic inflammatory bowel disease and/or bowel obstruction.
History of severe hypersensitivity reactions to Irinotecan hydrochloride trihydrate or to one of the excipients of Irinotecan Hydrochloride Trihydrate Injection 20 mg/mL.
Lactation.
Bilirubin >3 times the ULN.
Severe bone marrow failure.
WHO performance status >2.
Concomitant use with St John's Wort.
For additional contraindications of Cetuximab or Bevacizumab or Capecitabine, refer to the product information for these medicinal products.
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