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Pregnancy: As with all drugs propranolol should not be given during pregnancy unless its use is essential. There is no evidence of teratogenicity with propranolol. However, beta-blockers reduced placental perfusion, which may result in intra-uterine fetal death, immature and premature deliveries. In addition, adverse effects (especially hypoglycemia and bradycardia in the neonate and bradycardia in the fetus) may occur. There is an increased risk of cardiac and pulmonary complications in the neonate in the post-natal period.
Lactation: Most beta-adrenoceptor blocking drugs, particularly lipophilic compounds, will pass into breast milk although to a variable extent. Breast feeding is therefore not recommended following administration of these compounds.
Fertility: No relevant data on effect of fertility in humans is available.
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