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Treatment of diarrhea with loperamide-simethicone is only symptomatic. Whenever an underlying etiology can be determined, specific treatment should be given when appropriate.
In patients with (severe) diarrhea, fluid and electrolyte depletion may occur. In such cases the administration of appropriate fluid and electrolyte replacement should be considered.
If clinical improvement is not observed within 48 hours, the administration of loperamide-simethicone should be discontinued. Patients should be advised to consult their physician.
Patients with AIDS treated with loperamide-simethicone for diarrhea should have therapy stopped at the earliest signs of abdominal distension. There have been isolated reports of obstipation with an increased risk for toxic megacolon in AIDS patients with infectious colitis from both viral and bacterial pathogens treated with loperamide HCl.
This medicine must be used with caution in patients with hepatic impairment as it may result in a relative overdose leading to CNS toxicity.
Abuse and misuse, as an opioid substitute, have been described in individuals with opioid addiction.
When should the patient consult a doctor: If symptoms persist or worsen, or if new symptoms occur, stop use and consult a doctor.
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