Ilosone 200/Ilosone DS Overdosage

Ilosone DS: Signs and Symptoms: Symptoms of oral overdose of erythromycin estolate may include nausea, vomiting, epigastric distress and diarrhea. The severity of the epigastric distress and the diarrhea are dose related. Reversible mild acute pancreatitis has been reported. Hearing loss, with or without tinnitus and vertigo, may occur, especially in patients with renal or hepatic insufficiency.
Treatment: In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in the patient.
Unless 5 times the normal single dose of erythromycin estolate has been ingested, gastrointestinal decontamination should not be necessary. An accidental ingestion of erythromycin should not be predicted to have minimal toxicity unless there is a good approximation of how much was ingested and unless only a single medication was involved.
Protect the patient's airway and support ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient's vital signs, blood gases, serum electrolytes, etc. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which in many cases is more effective than emesis or lavage, consider charcoal instead of or in addition to gastric emptying. Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed. Safeguard the patient's airway when employing gastric emptying or charcoal.
Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for an overdose of erythromycin estolate.
Ilosone 200: Overdose and Treatment: In case of overdosage, erythromycin should be discontinued. Overdosage should be handled with the prompt elimination of unabsorbed drug and all other appropriate measures should be instituted. Erythromycin is not removed by peritoneal dialysis or hemodialysis.