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Pregnancy: Pregnancy Category B. Progesterone may delay spontaneous abortion of fertilized defective ova because of their uterine-relaxant effects. Also, the common cause of abortion in most women is defective ovum which progesterone could not be expected to influence.
There is evidence of potential adverse effects on the fetus when the drug is administered during the first 4 months of pregnancy. Prescription of progesterone beyond the first trimester of pregnancy may reveal gravidic cholestasis. A case of cleft palate was reported. When used for unapproved uses, rare cases of fetal death (causality not established) have been reported.
Lactation: Progesterone is excreted in human milk. Since the possible effects of progesterone on the breastfeeding infant have not been determined, caution should be exercised when progesterone is administered to breastfeeding mothers.
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