Oral Administration: Progesterone should be taken at bedtime. Do not administer with food. In women who experience difficulty swallowing the capsules, take the capsules with a glass of water while in standing position. (See Table 1.)

Vaginal Administration: Each progesterone capsule should be inserted deeply into the vagina. Rectal administration should be considered whenever vaginal administration is not possible. Concomitant use with other intravaginal preparations is not recommended since the possibility exists that there may be changes in the release and absorption of progesterone from the vaginal insert. (See Table 2.)
