Hepa-Merz Dosage/Direction for Use

Granules: The dissolved contents of 1-2 sachets of L-Ornithine-L-Aspartate (Hepa-Merz) granules are taken up to 3 times daily. L-Ornithine-L-Aspartate (Hepa-Merz) granules are dissolved in plenty of fluid (e.g. a glass of water, tea or juice) and taken with or after meals.
The experience on the use of the drug in children are limited.
Infusion: Unless otherwise indicated, patients may be given up to 4 ampoules per day. With incipient clouding of consciousness (precoma) or clouding of consciousness (coma), up to 8 ampoules may be given in 24 hours, depending on the severity of the condition.
The ampoules are added to an infusion solution before use, and infused in this form. L-Ornithine-L-Aspartate (Hepa-Merz) infusion concentrate can be mixed with the usual infusion solutions. So far no peculiarities have been observed with regard to miscibility. However, the ampoules should be admixed to the infusion solution only immediately before application. For venous tolerability, however, no more than 6 ampoules should be dissolved per 500 mL infusion. The maximum infusion rate is 5 g L-Ornithine-L-Aspartate (corresponding to the content of 1 ampoule) per hour. L-Ornithine-L-Aspartate (Hepa-Merz) infusion concentrate must not be administered into an artery. Experience in children is limited (see Precautions).