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Hepa-Merz

Hepa-Merz

l-ornithine-l-aspartate

Manufacturer:

Merz Pharmaceuticals

Distributor:

Zuellig
Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing
Concise Prescribing Info
Contents
L-ornithine-L-aspartate
Indications/Uses
Granules for oral soln: Treatment of concomitant disease & sequelae due to impaired hepatic detoxification activity (eg, in cirrhosis of the liver) w/ symptoms of latent & manifest hepatic encephalopathy. Conc for IV infusion: Treatment of hyperammonemia due to acute & chronic liver disease eg, liver cirrhosis, fatty liver, hepatitis, especially for the treatment of incipient disturbances of consciousness (pre-coma) or neurological complications (hepatic encephalopathy).
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Dosage/Direction for Use
Granules for oral soln 1-2 sachet, taken up to tid. Conc for IV infusion Up to 4 amp daily. Incipient clouding of consciousness (pre-coma) or clouding of consciousness (coma) Up to 8 amp may be given in 24 hr, depending on severity of the condition. Max infusion rate: 5 g/hr. For venous tolerability, no >6 amp should be dissolved per 500 mL infusion soln.
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Overdosage
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Administration
Should be taken with food: Granules for oral soln: Take w/ or after meals. Dissolve in a glass of water, tea or juice.
Contraindications
Hypersensitivity. Severely impaired renal function.
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Special Precautions
May impair ability to drive & use machines. Avoid use during pregnancy & lactation. No data available for use in childn. Granules for oral soln: Should not be given to patients w/ rare hereditary problems of fructose intolerance. Consider fructose content in DM patients. Long-term use may be harmful to the teeth (caries). Conc for IV infusion: Monitor serum & urine urea levels at high doses. Infusion rate must be adjusted in patients w/ substantially impaired liver function to prevent nausea & vomiting.
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Use In Pregnancy & Lactation
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Adverse Reactions
Granules for oral soln: Uncommon: Nausea, vomiting, stomachache, flatulence, diarrhea. Conc for IV infusion: Uncommon: Nausea.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Hepa-Merz detailed prescribing information
Storage
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Description
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Action
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MIMS Class
Cholagogues, Cholelitholytics & Hepatic Protectors
ATC Classification
A05BA06 - ornithine oxoglurate ; Belongs to the class of drugs used in liver therapy.
Regulatory Classification
Rx
Presentation/Packing
Form
Hepa-Merz granules for oral soln 3 g
Packing/Price
10 × 1's
Form
Hepa-Merz conc for IV infusion 5 g/10 mL
Packing/Price
(amp) 5 × 1's