Because of the incompatibility of oxaliplatin to sodium chloride and alkaline solution (eg, 5-fluorouracil), it should not be mixed with these agents or administered through same vein at the same time. In vitro study shows that no significant change occurs in protein-binding in the presence of erythromycin, salicylate, paclitaxel and sodium valproate. In vivo, animal and human study shows in combination with 5-fluorouracil, oxaliplatin exhibits synergic action.