Henplatin Adverse Reactions

Hemopoietic System: It exhibits a certain extent of hematologic toxicity. Monotherapy may cause the following adverse reactions: Anemia, leukocytosis, granulocytopenia, thrombopenia, sometimes grade 3 and 4. In combination with 5-fluorouracil, the incidence of hematology toxicity events increases, including neutrophilic granulocytopenia and thrombocytopenia, etc.
Digestive System: Single administration of the agent may cause nausea, vomiting and diarrhea, which is sometimes very severe. When in combination with 5-fluorouracil, the adverse reactions increase significantly. Preventive or therapeutic antiemetic is recommended.
Nervous System: Peripheral and sensory neuropathy that is characterized by peripheral neuritis. These symptoms may be accompanied by convulsion and sensory disturbance around the mouth, at upper respiratory tract and upper digestive tract; even clinical conditions similar to laryngeal spasm, which may recover and without sequelae. These symptoms may often be severe. Abnormal sensation may relieve during resting period of treatment and when cumulative dose is over 800 mg/m² (6 cycles), permanent abnormal sensation or dysfunction may be caused. Several months after termination of treatment, neurotoxicity of over 3/4 patients is relieved and disappears. When reversible abnormal sensation occurs, it is not necessary to adjust the dosage of next administration. Dosage adjustment should be based on the duration and severity of observed neurotoxicity. If abnormal sensation occurs and continues during 2 periods of treatment and aching abnormal sensation and/or dysfunction begins to occur, the dose should be decreased by 25% (or 100 mg/m²). After symptoms partly or completely disappear, there is still possibility of administering the drug (full or decreased dose) depending on the physician's judgement.