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Pharmacology: Pharmacodynamics: Chlorhexidine is effective against a wide range of Gram negative and Gram positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures.
Pharmacokinetics: Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus poorly absorbed. No detectable blood levels have been found in man following oral use and percutaneous absorption, if it occurs at all, is insignificant.
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