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Each ml contains 500 mcg of eribulin mesilate (equivalent to 440 mcg of eribulin).
It also contains 5% dehydrated alcohol.
Each 2 mL vial contains 1 mg of eribulin mesilate (equivalent to 880 mcg of eribulin).
Non Proprietary name: Eribulin mesilate.
Chemical name: (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2S)-3-Amino-2-hydroxypropyl]-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one monomethanesulfonate.
Molecular formula: C40H59NO11·CH4O3S.
Molecular weight: 826.00.
Eribulin mesilate is a white powder and freely soluble in water, methanol, ethanol, 1-octanol, benzyl alcohol, dichloromethane, dimethylsulfoxide, N-methylpyrrolidone and ethyl acetate. It is soluble in acetone, sparingly soluble in acetonitrile and practically insoluble in tert-butyl methyl ether, n-hepatane and n-pentane.
Melting point: about 160°C (with decomposition).
Partition coefficient: 2.25 (Octanol: buffer, ion strength 0.3).
Excipients/Inactive Ingredients: It contains dehydrated alcohol, water for injection and hydrochloric acid, sodium hydroxide (for pH adjustment).
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