H2Bloc Dosage/Direction for Use

Tablet: Ulcer: Adults: Treatment: Usual Recommended Dose: 40 mg (2 tablets) daily at bedtime. Treatment may last 4-8 weeks depending on patient's response.
A dose of 20 mg twice daily has also been given.
Maintenance Dose: 20 mg daily at bedtime.
Children 1-16 years: Initial dose of 0.5 mg/kg per day, either in a single dose at night or in two divided doses; up to 40 mg per day may be given.
GERD: Adults: Treatment: 20 mg two times a day (one tablet in the morning and one tablet at bedtime) for 6 to 12 weeks, or up to 40 mg two times a day if there is esophageal erosion or ulceration.
Maintenance dose: 20 mg two times a day (one tablet in the morning and one tablet at bedtime).
Pathological Hypersecretory Conditions: 20 mg every six hours, increased as necessary and continued as long as it is clinically indicated; doses up to 800 mg per day have been used.
Patients with renal impairment: To avoid excess accumulation of the drug in patients with moderate and severe renal impairment, the dose of famotidine may be reduced to half the dose or the dosing may be prolonged to 36 to 48 hours as indicated by the patient's clinical response. Dialysis patients should also take half the recommended dose. Famotidine tablets should be administered at the end of dialysis or later since some of the active ingredient is removed by dialysis.
Injection: Recommended Adult Parenteral Dose: 20 mg every 12 hours.
Suggested Parenteral Famotidine Starting Dose in Children 1 to 16 years old: An initial dose of 0.25 mg/kg is suggested for GERD, given by injection over at least 2 minutes or as an infusion over 15 minutes, and repeated every 12 hours. Up to 40 mg per day may be given. Or, as prescribed by a physician
Administration: Tablet: If the patient missed a dose, take the next dose as scheduled. Do not double the dose. Do not take more than the recommended dose.
Injection: Famotidine injection should be administered by slow IV injection (not <2 min), by slow IV infusion (15-30 min) or by IM injection.
Dosage must be adjusted based on age, patient's response and/or gastric or esophageal pH determination and endoscopy to meet individual patient requirement.
Parenteral famotidine should be shifted to oral famotidine as soon as feasible.
Inspect the solution for particulate matter and discoloration before administration.
Preparation and Directions for Reconstitution: IV Injection: Dissolve powder in 20 mL physiological saline injection or 5% dextrose injection.
IV Infusion: Dissolve powder in 20 mL physiological saline injection or 5% dextrose injection and dilute further to 100 mL using either IV fluid.
IM Injection: Dissolve powder in 1-1.5 mL sterile water for injection.