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Overdose may precipitate hypoglycemia due to the presence of sulfonylurea.
High overdose or the existence of concomitant risk factors may lead to lactic acidosis due to the presence of metformin. Lactic acidosis is a medical emergency and must be treated in a hospital. The most effective treatment is to remove lactate and metformin by hemodialysis.
The plasma clearance of glibenclamide may be prolonged in patients suffering from liver disease. Since glibenclamide is extensively bound to proteins, it is not eliminated by dialysis.
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