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Patients who require concomitant treatment with CNS depressants such as opiates or benzodiazepines should be informed that they may experience additive CNS side effects, such as somnolence.
Pregabalin may potentiate the effects of ethanol and lorazepam.
There are also some reports of respiratory failure and coma in patients taking pregabalin and other CNS depressant medications.
Pregabalin appears to be additive in the impairment of cognitive and gross motor function caused by oxycodone.
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