Gabica Dosage/Direction for Use

Pregabalin (Gabica) is given orally with or without food.
When discontinuing Pregabalin (Gabica), taper gradually over a minimum of 1 week irrespective of the indication.
Neuropathic Pain Associated with Diabetic Peripheral Neuropathy: Pregabalin (Gabica) treatment can be started at a dose of 150 mg per day, given as 2-3 divided doses. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day, given as 2 divided doses, after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg per day after an additional 7 days interval.
Postherpetic Neuralgia: The recommended dose of Pregabalin (Gabica) is 75 to 150 mg two times a day or 50 to 100 mg three times a day (150 to 300 mg/day). Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day and who are able to tolerate Pregabalin (Gabica), may be treated with up to 300 mg two times a day (600 mg/day).
Adjunctive therapy in adults with partial seizure with or without secondary generalization: Pregabalin (Gabica) treatment can be started with a dose of 150 mg per day given as 2-3 divided doses. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day after 1 week. The maximum dosage of 600 mg per day may be achieved after an additional week.
Pregabalin (Gabica) does not alter the plasma concentrations of other commonly used anti-convulsant drugs. Similarly, commonly used anticonvulsant drugs do not alter plasma concentrations of Pregabalin (Gabica).
General Anxiety Disorder: The dose range is 150 to 600 mg/day given as two or three divided doses. The need for treatment should be reassessed regularly. Pregabalin (Gabica) treatment can be started with a dose of 150 mg/day given as 2-3 divided doses. Based on individual patient response and tolerability, the dosage may be increased to 300 mg/day after 1 week. Following an additional week the dosage may be increased to 450 mg/day. The maximum dosage of 600 mg/day may be achieved after an additional week.
Fibromyalgia Syndrome (FMS): The recommended dose of Pregabalin (Gabica) for fibromyalgia is 300 to 450 mg/day given in two divided doses. Some patients may derive additional benefit at 600 mg per day. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). If needed, in some patients, based on individual response and tolerability, the dose may be increased to maximum dosage of 600 mg/day after an additional week.
Renally Impaired Patients: As Pregabalin (Gabica) clearance is directly proportional to creatinine clearance, dosage reduction in patients with compromised renal function must be individualised according to creatinine clearance, as indicated in table as follows determined using the following formula: see equation and table.

Click on icon to see table/diagram/image


Click on icon to see table/diagram/image