Frusema Mechanism of Action

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Full Prescribing Info

Action

Pharmacology: Furosemide is a potent diuretic with a rapid action. Its effect are evident within 1 hour after a dose by mouth and for about 4 to 6 hours; also promote the excretion of water and electrolytes by the kidneys. Used in treating patients with congestive heart failure, renal or pulmonary disease when salt and water retention has resulted in edema and ascites. Furosemide is incompletely but fairly rapidly absorbed from the gastrointestinal tract. It has a biphasic half-life in a plasma with a terminal elimination phase that has been estimated to range to 1 1/2 hours. It is up to 99% bound to plasma protein and is mainly excreted in the urine, largely unchanged, but also in the form of the glucuronide and free amine metabolites. Variable amount are also excreted in the bile, non-renal elimination being considerably increased in the renal failure. Furosemide crosses the placental barrier and is excreted in milk.

furosemide

Manufacturer:

Am-Europharma

Distributor:

RiteMED