Furosemide may enhance the nephrotoxicity of cephalosporin antibacterials such as cefalotin and can enhance the ototoxicity of aminoglycoside antibacterials and other ototoxic drugs. The interactions of furosemide that are due to its effects on fluids and electrolyte balance are similar to those of hydrochlorothiazide. Diuretic-induced hypokalemia may enhance the toxicity of digitalis glycosides and may also increase the risk of arrhythmias with drugs that prolong the QT interval such as astemizole, terfenadine, halofantrine, pimozide, and sotalol.