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Make a careful inquiry about previous hypersensitivity reactions to cephalosporins and penicillins before instituting ceftriaxone therapy. Generally, cephalosporins may be given safely to patient who are hypersensitive to penicillins, although cross-reactions have been reported. Any patient who has demonstrated some form of allergy, particularly to drugs, should receive antibiotics, eg ceftriaxone cautiously. Discontinue ceftriaxone if an allergic reaction occurs. Serious hypersensitivity reactions may require epinephrine and other measures.
Like most broad-spectrum antibiotics, prolonged use may give rise to pseudomembranous colitis due to overgrowth of Clostridium difficile. Mild cases usually respond to drug discontinuation. Moderate to severe cases may need fluid and electrolyte supplementation.
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