Forgram Adverse Reactions

Ceftriaxone is generally well tolerated.
Local Reaction: Pain, induration and tenderness (1%). Phlebitis after IV administration (1%). Incidence of injection site reactions were 17% after 350 mg/mL and 5% after 250 mg/mL, both are IM administration.
Hypersensitivity: Rash (1.7%). Less frequently (<1%), pruritus, fever or chills.
Gastrointestinal: Diarrhea (27%), less frequently (<1%), nausea, vomiting and perversion to the sense of taste. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.
Hematologic: Eosinophilia (6%), thrombocytosis (5.1%), and leukopenia (2.1%). Less frequently (<1%), anemia, hemolytic anemia, neutropenia, lymphopenia, thrombocytopenia and prolongation of the prothrombin time.
Hepatic: Elevations of AST (3.1%) and ALT (3.3%). Less frequently (<1%), elevations of alkaline phosphatase and bilirubin.
Renal: Elevations of BUN (1.2%). Less frequently (<1%), elevations of creatinine and the presence of casts in the urine.
CNS: Occasionally (<1%), headache or dizziness.
Genitourinary: Occasionally (<1%), moniliasis or vaginitis.
Miscellaneous: Occasionally (<1%), diaphoresis and flushing.
Rarely (<0.1%), adverse events include leukocytosis, lymphocytosis, monocytosis, basophilia, a decrease in prothrombin time, jaundice, gallbladder sludge, glycosuria, hematuria, anaphylaxis, bronchospasm, serum sickness, abnormal pain, colitis, flatulence, dyspepsia, palpitations and epistaxis.