For the treatment and prevention of folate, Vitamins B1, B6 and B12 deficiency states. For supplementation where Folate and Vitamin B12 are reduced due to intake of certain medications such as Fenofibrate, Metformin and Methotrexate. For lowering homocysteine levels to reduce risk of cardiovascular diseases, myocardial infarction, stroke, peripheral arterial vascular disease, and endothelial dysfunction, a common feature of type II diabetes. To regulate homocysteine levels in patients with chronic renal failure and to improve their response to recombinant human erythropoietin (rhEPO) therapy. Used as prophylactic where the vitamin requirements such as folic acid are increased, especially during pregnancy, and to prevent and reduce incidence of neural tube defects. Used in the treatment of megaloblastic anemias which may result from malabsorption syndromes such as sprue, idiopathic steatorrhea, celiac disease, intestinal reticulosis, regional jejunitis, jejunal diverticulosis, blind loop syndrome, and gastroenterostomy.