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Folate deficiency states may be produced by drugs such as antiepileptics, oral contraceptives, antituberculous drugs, alcohol and folic acid antagonists such as methotrexate, pyrimethamine, triamterene, trimethoprim, and sulfonamides.
Pyridoxine reduces the effects of levodopa but this does not occur if a dopa decarboxylase inhibitor is also given. Pyridoxine reduces the activity of altretamine. It also decreases serum concentrations of phenobarbital. Many drugs may increase the requirements for pyridoxine such as hydralazine, isoniazid, penecillamine, and oral contraceptives.
Absorption of Vitamin B12 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists. omeprazole, and colchicine. Serum concentrations may be decreased by use of oral contraceptives.
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